Tryptophan hydroxylase

tryptophan 5-monooxygenase
tryptophan 5-monooxygenase monomer, Human
Identifiers
EC no.	1.14.16.4
CAS no.	9037-21-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)
Identifiers
Symbol	TPH1
Alt. symbols	TPRH, TPH
NCBI gene	7166
HGNC	12008
OMIM	191060
PDB	1MLW
RefSeq	NM_004179
UniProt	P17752
Other data
EC number	1.14.16.4
Locus	Chr. 11 p15.3-p14
Search for Structures Swiss-model Domains InterPro

tryptophan hydroxylase 2
Identifiers
Symbol	TPH2
NCBI gene	121278
HGNC	20692
OMIM	607478
RefSeq	NM_173353
UniProt	Q8IWU9
Other data
Locus	Chr. 12 q15
Search for Structures Swiss-model Domains InterPro

Tryptophan hydroxylase (TPH) is an enzyme (EC 1.14.16.4) involved in the synthesis of the monoamine neurotransmitter serotonin. Tyrosine hydroxylase, phenylalanine hydroxylase, and tryptophan hydroxylase together constitute the family of biopterin-dependent aromatic amino acid hydroxylases. TPH catalyzes the following chemical reaction

L-tryptophan + tetrahydrobiopterin + O₂ ${\displaystyle \rightleftharpoons }$ 5-Hydroxytryptophan + dihydrobiopterin + H₂O

It employs one additional cofactor, iron.